CSPM EDP Sciences logo
Access to submission and peer review system
Search
Menu
All issues Volume 3 (2022) Vis Cancer Med, 3 (2022) 2 References
Open Access
Review
Issue
Vis Cancer Med
Volume 3, 2022
Article Number 2
Number of page(s) 5
DOI https://doi.org/10.1051/vcm/2022002
Published online 06 April 2022
  1. Lindenmann J. Resistance of mice to mouse-adapted influenza A virus. Virology. 1962;16:203–204. [CrossRef] [Google Scholar]
  2. Staeheli P, Grob R, Meier E, et al. Influenza virus-susceptible mice carry Mx genes with a large deletion or a nonsense mutation. Molecular and Cellular Biology. 1988;8(10):4518–4523. [PubMed] [Google Scholar]
  3. Aebi M, Fah J, Hurt N, et al. cDNA structures and regulation of two interferon-induced human Mx proteins. Molecular and Cellular Biology. 1989;9(11):5062–5072. [PubMed] [Google Scholar]
  4. Horisberger MA, Wathelet M, Szpirer J, et al. cDNA cloning and assignment to chromosome 21 of IFI-78K gene, the human equivalent of murine Mx gene. Somatic Cell and Molecular Genetics. 1988;14(2):123–131. [CrossRef] [PubMed] [Google Scholar]
  5. Stertz S, Reichelt M, Krijnse-Locker J, et al. Interferon-induced, antiviral human MxA protein localizes to a distinct subcompartment of the smooth endoplasmic reticulum. Journal of Interferon & Cytokine Research: The Official Journal of the International Society for Interferon and Cytokine Research. 2006;26(9):650–660. [CrossRef] [PubMed] [Google Scholar]
  6. Pavlovic J, Zurcher T, Haller O, et al. Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein. Journal of Virology. 1990;64(7):3370–3375. [CrossRef] [PubMed] [Google Scholar]
  7. Pavlovic J, Haller O, Staeheli P. Human and mouse Mx proteins inhibit different steps of the influenza virus multiplication cycle. Journal of Virology. 1992;66(4):2564–2569. [CrossRef] [PubMed] [Google Scholar]
  8. Frese M, Kochs G, Meier-Dieter U, et al. Human MxA protein inhibits tick-borne Thogoto virus but not Dhori virus. Journal of Virology. 1995;69(6):3904–3909. [CrossRef] [PubMed] [Google Scholar]
  9. Schnorr JJ, Schneider-Schaulies S, Simon-Jodicke A, et al. MxA-dependent inhibition of measles virus glycoprotein synthesis in a stably transfected human monocytic cell line. Journal of Virology. 1993;67(8):4760–4768. [CrossRef] [PubMed] [Google Scholar]
  10. Frese M, Kochs G, Feldmann H, et al. Inhibition of bunyaviruses, phleboviruses, and hantaviruses by human MxA protein. Journal of Virology. 1996;70(2):915–923. [CrossRef] [PubMed] [Google Scholar]
  11. Hefti HP, Frese M, Landis H, et al. Human MxA protein protects mice lacking a functional alpha/beta interferon system against La crosse virus and other lethal viral infections. Journal of Virology. 1999;73(8):6984–6991. [CrossRef] [PubMed] [Google Scholar]
  12. Landis H, Simon-Jodicke A, Kloti A, et al. Human MxA protein confers resistance to Semliki Forest virus and inhibits the amplification of a Semliki Forest virus-based replicon in the absence of viral structural proteins. Journal of Virology. 1998;72(2):1516–1522. [CrossRef] [PubMed] [Google Scholar]
  13. Mundt E. Human MxA protein confers resistance to double-stranded RNA viruses of two virus families. The Journal of General Virology. 2007;88(Pt 4):1319–1323. [CrossRef] [PubMed] [Google Scholar]
  14. Netherton CL, Simpson J, Haller O, et al. Inhibition of a large double-stranded DNA virus by MxA protein. Journal of Virology. 2009;83(5):2310–2320. [CrossRef] [PubMed] [Google Scholar]
  15. Li N, Zhang L, Chen L, et al. MxA inhibits hepatitis B virus replication by interaction with hepatitis B core antigen. Hepatology. 2012;56(3):803–811. [CrossRef] [PubMed] [Google Scholar]
  16. Gordien E, Rosmorduc O, Peltekian C, et al. Inhibition of hepatitis B virus replication by the interferon-inducible MxA protein. Journal of Virology. 2001;75(6):2684–2691. [CrossRef] [PubMed] [Google Scholar]
  17. Mitchell PS, Emerman M, Malik HS. An evolutionary perspective on the broad antiviral specificity of MxA. Current Opinion in Microbiology. 2013;16(4):493–499. [CrossRef] [PubMed] [Google Scholar]
  18. Zav’yalov VP, Hamalainen-Laanaya H, Korpela TK, et al. Interferon-inducible myxovirus resistance proteins: potential biomarkers for differentiating viral from bacterial infections. Clinical Chemistry. 2019;65(6):739–750. [CrossRef] [PubMed] [Google Scholar]
  19. Sistigu A, Yamazaki T, Vacchelli E, et al. Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy. Nature Medicine. 2014;20(11):1301–1309. [CrossRef] [PubMed] [Google Scholar]
  20. Kim YA, Lee HJ, Heo SH, et al. MxA expression is associated with tumor-infiltrating lymphocytes and is a prognostic factor in triple-negative breast cancer. Breast Cancer Research and Treatment. 2016;156(3):597–606. [CrossRef] [PubMed] [Google Scholar]
  21. Mushinski JF, Nguyen P, Stevens LM, et al. Inhibition of tumor cell motility by the interferon-inducible GTPase MxA. The Journal of Biological Chemistry. 2009;284(22):15206–15214. [CrossRef] [PubMed] [Google Scholar]
  22. Kochs G, Haller O. GTP-bound human MxA protein interacts with the nucleocapsids of Thogoto virus (Orthomyxoviridae). The Journal of Biological Chemistry. 1999;274(7):4370–4376. [CrossRef] [PubMed] [Google Scholar]
  23. Deeg CM, Hassan E, Mutz P, et al. In vivo evasion of MxA by avian influenza viruses requires human signature in the viral nucleoprotein. The Journal of Experimental Medicine. 2017;214(5):1239–1248. [CrossRef] [PubMed] [Google Scholar]
  24. Turan K, Mibayashi M, Sugiyama K, et al. Nuclear MxA proteins form a complex with influenza virus NP and inhibit the transcription of the engineered influenza virus genome. Nucleic Acids Research. 2004;32(2):643–652. [CrossRef] [PubMed] [Google Scholar]
  25. Zimmermann P, Manz B, Haller O, et al. The viral nucleoprotein determines Mx sensitivity of influenza A viruses. Journal of Virology. 2011;85(16):8133–8140. [CrossRef] [PubMed] [Google Scholar]
  26. Manz B, Dornfeld D, Gotz V, et al. Pandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoprotein. PLoS Pathogens. 2013;9(3):e1003279. [CrossRef] [PubMed] [Google Scholar]
  27. Zheng W, Tao YJ. Structure and assembly of the influenza A virus ribonucleoprotein complex. FEBS Letters. 2013;587(8):1206–1214. [CrossRef] [PubMed] [Google Scholar]
  28. Fuchs J, Oschwald A, Graf L, et al. Tick-transmitted thogotovirus gains high virulence by a single MxA escape mutation in the viral nucleoprotein. PLoS Pathogens. 2020;16(11):e1009038. [CrossRef] [PubMed] [Google Scholar]
  29. Kochs G, Janzen C, Hohenberg H, et al. Antivirally active MxA protein sequesters La Crosse virus nucleocapsid protein into perinuclear complexes. Proceedings of the National Academy of Sciences of the United States of America. 2002;99(5):3153–3158. [CrossRef] [PubMed] [Google Scholar]
  30. Reichelt M, Stertz S, Krijnse-Locker J, et al. Missorting of LaCrosse virus nucleocapsid protein by the interferon-induced MxA GTPase involves smooth ER membranes. Traffic. 2004;5(10):772–784. [CrossRef] [PubMed] [Google Scholar]
  31. Frese M, Pietschmann T, Moradpour D, et al. Interferon-alpha inhibits hepatitis C virus subgenomic RNA replication by an MxA-independent pathway. The Journal of General Virology. 2001;82(Pt 4):723–733. [CrossRef] [PubMed] [Google Scholar]
  32. Hoenen A, Liu W, Kochs G, et al. West Nile virus-induced cytoplasmic membrane structures provide partial protection against the interferon-induced antiviral MxA protein. The Journal of General Virology. 2007;88(Pt 11):3013–3017. [CrossRef] [PubMed] [Google Scholar]
  33. Hoenen A, Gillespie L, Morgan G, et al. The West Nile virus assembly process evades the conserved antiviral mechanism of the interferon-induced MxA protein. Virology. 2014;448:104–116. [CrossRef] [Google Scholar]
  34. Kochs G, Haener M, Aebi U, et al. Self-assembly of human MxA GTPase into highly ordered dynamin-like oligomers. The Journal of Biological Chemistry. 2002;277(16):14172–14176. [CrossRef] [PubMed] [Google Scholar]
  35. Accola MA, Huang B, Al Masri A, et al. The antiviral dynamin family member, MxA, tubulates lipids and localizes to the smooth endoplasmic reticulum. The Journal of biological chemistry. 2002;277(24):21829–21835. [CrossRef] [PubMed] [Google Scholar]
  36. von der Malsburg A, Abutbul-Ionita I, Haller O, et al. Stalk domain of the dynamin-like MxA GTPase protein mediates membrane binding and liposome tubulation via the unstructured L4 loop. The Journal of Biological Chemistry. 2011;286(43):37858–37865. [CrossRef] [PubMed] [Google Scholar]
  37. Dick A, Graf L, Olal D, et al. Role of nucleotide binding and GTPase domain dimerization in dynamin-like myxovirus resistance protein A for GTPase activation and antiviral activity. The Journal of Biological Chemistry. 2015;290(20):12779–12792. [CrossRef] [PubMed] [Google Scholar]
  38. Gao S, von der Malsburg A, Paeschke S, et al. Structural basis of oligomerization in the stalk region of dynamin-like MxA. Nature. 2010;465(7297):502–506. [CrossRef] [PubMed] [Google Scholar]
  39. Gao S, von der Malsburg A, Dick A, et al. Structure of myxovirus resistance protein a reveals intra- and intermolecular domain interactions required for the antiviral function. Immunity. 2011;35(4):514–525. [CrossRef] [PubMed] [Google Scholar]
  40. Patzina C, Haller O, Kochs G Structural requirements for the antiviral activity of the human MxA protein against Thogoto and influenza A virus. The Journal of Biological Chemistry. 2014;289(9):6020–6027. [CrossRef] [PubMed] [Google Scholar]
  41. Chen Y, Zhang L, Graf L, et al. Conformational dynamics of dynamin-like MxA revealed by single-molecule FRET. Nature Communications. 2017;8:15744. [CrossRef] [PubMed] [Google Scholar]
  42. Daumke O, Gao S, von der Malsburg A, et al. Structure of the MxA stalk elucidates the assembly of ring-like units of an antiviral module. Small GTPases. 2010;1(1):62–64. [CrossRef] [PubMed] [Google Scholar]
  43. Alvarez FJD, He S, Perilla JR, et al. CryoEM structure of MxB reveals a novel oligomerization interface critical for HIV restriction. Science Advances. 2017;3(9):e1701264. [CrossRef] [PubMed] [Google Scholar]
  44. Rennie ML, McKelvie SA, Bulloch EM, et al. Transient dimerization of human MxA promotes GTP hydrolysis, resulting in a mechanical power stroke. Structure. 2014;22(10):1433–1445. [CrossRef] [PubMed] [Google Scholar]
  45. Haller O, Kochs G. Human MxA protein: an interferon-induced dynamin-like GTPase with broad antiviral activity. Journal of Interferon & Cytokine Research: The Official Journal of the International Society for Interferon and Cytokine Research. 2011;31(1):79–87. [CrossRef] [PubMed] [Google Scholar]

Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.

Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.

Initial download of the metrics may take a while.