Issue |
Vis Cancer Med
Volume 4, 2023
|
|
---|---|---|
Article Number | 2 | |
Number of page(s) | 2 | |
DOI | https://doi.org/10.1051/vcm/2022006 | |
Published online | 06 January 2023 |
Perspective Article
WTX beyond WNT signaling pathway
1
Department of General Surgery, The Third Affiliated Hospital of Southern Medical University, Guangdong Province, People’s Republic of China
2
First Affiliated Hospital of Xinxiang Medical College, Xinxiang, Henan 453100, China
3
Department of Pathology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong Province, People’s Republic of China
* Corresponding author: zhangqingling@gdph.org.cn
Received:
13
May
2022
Accepted:
10
October
2022
Gastric cancer (GC) is a major malignancy in many developing countries with low early detection rate. As a tumour suppressor gene, WTX inhibits PI3K/AKT/mTOR pathway activity by inhibiting PI3K phosphorylation. WTX loss of WTX protein associates with tumor metastasis and poor survival of GC patients. During GC progression, an aberrantly elevated miR-20a-5p expression has been found, which inhibits WTX expression and induces PI3K phosphorylation, thereby activating the PI3K/AKT/mTOR pathway and promoting cellular proliferation and migration. A new mechanism in which miR-20a-5p promotes GC progression by regulating WTX expression to control PI3K/AKT/mTOR pathway activity has been recently discovered. These findings might be useful for developing novel therapeutics to inhibit the progression of GC.
Key words: Gastric cancer / PI3K/AKT / WTX/AMER1 / miR-20a-5p
© The Authors, published by EDP Sciences, 2023
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