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Table 2
Summary of literature on oral carcinoma cuniculatum [6].
| Author | Sex | Age | Location | Bone involvement | Initial diagnosis | Risk factors | Recurrence | Mets |
|---|---|---|---|---|---|---|---|---|
| Flieger et al. 1977 | M | 50 | Alveolus | Yes | Osteomyelitis | N/A | N/A | N0M0 |
| M | 60 | Alveolus | Yes | Tuberculosis | Poor oral hygiene | N/A | N0M1 | |
| M | 9 | Alveolus | Yes | N/A | N/A | N/A | N0M0 | |
| F | 69 | Hard palate | Yes | N/A | N/A | N/A | N0M0 | |
| Kuffer et al. 1984 | M | 43 | Alveolus | N/A | N/A | N/A | N/A | – |
| M | 68 | Alveolus | N/A | N/A | N/A | N/A | – | |
| M | 16 | RMT | N/A | N/A | N/A | N/A | – | |
| F | 44 | Tongue | N/A | N/A | N/A | N/A | – | |
| F | 44 | Epiglottis | N/A | N/A | N/A | N/A | – | |
| Kahn et al. 1991 | M | 62 | Alveolus | Yes | Cyst | Yes | N0M0 | |
| F | 49 | Alveolo- lingual groove | Yes | WD- EC | Alcohol- smoking | No | N0M0 | |
| M | 52 | Floor of mouth | Yes | WD-EC | N/A | No | N0M0 | |
| F | 54 | Alveolo- lingual groove | Yes | None | N/A | No | N0M0 | |
| Delahaye et al. 1994 | M | 51 | RMT | N/A | WD-EC | Alcohol- smoking | Yes | N1M0 |
| M | 55 | Tongue + floor of mouth | N/A | VC | N/A | Yes | N0M0 | |
| M | 31 | Hard palate | No | WD-EC | N/A | No | N0M0 | |
| M | 63 | Larynx | N/A | N/A | N/A | N/A | N0M0 | |
| M | 52 | Cheek mucosa | N/A | N/A | Alcohol- smoking | N/A | N0M0 | |
| Huault et al. 1998 | F | 55 | Alveolus | Yes | Papilloma | Tooth extraction | No | N1M0 |
| Allon et al. 2002 | M | 56 | Alveolus | Yes | None | N/A | No | N0M0 |
| Gallo et al. 2005 | M | 47 | Lips + cheek | Yes | None | N/A | Yes | – |
| Raguse et al. 2006 | F | 81 | Mandibular symphysis | Yes | N/A | N/A | N/A | – |
| Puxeddu et al. 2008 | M | 72 | Larynx | N/A | Pseudo- epithelial hyperplasia | N/A | N/A | N0M0 |
| Kruse et al. 2009 | F | 74 | Maxilla | Yes | EC | None | No | N0M0 |
| Hutton et al. 2010 | F | 7 | Maxilla | Yes | Cyst | None | No | N0M0 |
| Pons et al. 2010 | M | 72 | Mandible | Yes | Abscess | N/A | No | N0M0 |
| M | 82 | Mandible | Yes | Cyst | N/A | No | N0M0 | |
| M | 43 | RMT | Yes | Cyst | N/A | No | N0M0 | |
| Sun et al. 2011 | 7 M 8F | 67 | 8 tongue 6 mandible 1 vestibule | 5 Yes 10 No | 3N1M0 12N0M0 | |||
| Thavaraj et al. 2011 | M | 61 | Tongue | No | N/A | N/A | No | |
| Suzuki et al. 2012 | M | 68 | Alveolus | Yes | Osteomyelitis | Alcohol- smoking | Yes | N0M0 |
| Fonseca et al. 2013 | F | 62 | Mandibule | Yes | super-infected cyst | None | No | N0M0 |
| F | 47 | Alveolus | Yes | Osteomyelitis | None | No | – | |
| Padilla et al. 2014 | M | 65 | Alveolus | N/A | Hyperkeratosis | N/A | N/A | – |
| F | 38 | Alveolus | No | Hyperplakia | None | NA | – | |
| M | 72 | Alveolus | No | N/A | None | No | – | |
| F | 81 | Alveolus | No | N/A | None | No | – | |
| F | 65 | Alveolus | N/A | Lichen planus | None | N/A | – | |
| M | 79 | Alveolus | Yes | N/A | Alcohol – | No | – | |
| smoking | ||||||||
| F | 88 | Alveolus | No | N/A | None | No | – | |
| F | 75 | Alveolus | No | Dysplasia | Smoking | No | – | |
| F | 69 | Alveolus | No | N/A | None | No | – | |
| F | 85 | Alveolus | No | N/A | None | N/A | – | |
| Shay et al. 2015 | M | 58 | Mandible | Yes | Odontogenic Keratocyst | None | Yes | N0M0 |
| Shapiro et al. 2015 | F | 71 | Para- symphysis | Yes | Leucoplakia | Smoking | N/A | N0M0 |
| Datar et al. 2017 | F | 58 | Right gingiva | Yes | SCC | No | N/A | N0M0 |
| Thibouw et al. 2018 | M | 57 | Lower lip | Yes | scar-like inflammatory suspected mycetoma | Smoking | No | |
| Zhang et al. 2018 | M | 39 | Lower gingiva | Yes | SCC | Smoker | No | N1M0 |
| Ajith et al. 2018 | M | 71 | Tongue | Yes | Multiple inconclusive biopsies | No | Yes | N1M0 |
| M | 63 | Mandible | Yes | Odontogenic keratocyst | No | Yes | N0M0 | |
| Broly et al. 2019 | M | 78 | Dental pain in second mandibular region | Yes | Odontogenic infection | Smoking and Alcohol | No | N0M0 |
| Sivapathasundharam | F | 47 | Lower tooth | Erosion | NA | None | No | – |
| et al. 2019 | ||||||||
| Barrett et al 2020 | M | 78 | Mandible | Yes | N/A | N/A | N/A | N0M0 |
| M | 71 | Mandible | Yes | Verrucous leukoplakia | N/A | N/A | N0M0 | |
| F | 94 | Mandible | Yes | N/A | N/A | N/A | N0M0 | |
| M | 69 | Mandible | Yes | N/A | N/A | N/A | N0M0 | |
| Janardhanan et al. 2021 | M | 63 | Right lower jaw | Yes | Odontogenic kerato cyst | N/A | Yes | N0M0 |
| Yadav et al. 2021 | M | 41 | Tongue | No | WDSCC | Tobacco | No | N0M0 |
| M | 37 | Tongue | No | Hyperplastic squamous epithelium | Tobacco, betel quid | Yes | N1M0 | |
| F | 45 | Palate | No | WD SCC | Betel-leaf | No | N0M0 | |
| M | 45 | Right lower GBS | Yes | Hyperplastic squamous epithelium | Smoking; alcohol | No | N1M0 | |
| M | 77 | Left upper GBS | No | WDSCC | Tobacco | No | N0M0 | |
| M | 25 | Right buccal mucosa | No | Atypical squamous | Tobacco | No | N0M0 | |
| Malhotra et al. (present study) | M | 60 | Left Buccal Mucosa | No | WDSCC | Tobacoo | No | N0M0 |
| M | 62 | Right Buccal Mucosa | Yes | WDSCC | Tobacoo | No | N0M0 | |
| M | 46 | Left Buccal Mucosa | No | WDSCC | Smoker | No | N0M0 | |
| F | 71 | Upper GBS | Yes | MDSCC | Betel leaf | No | N0M0 | |
| F | 72 | Lower GBS and RMT | Yes | MDSCC | Betel leaf | Yes | N0M0 |
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