Open Access
Review
Table 1
Different types of nanocarriers in drug delivery system for colorectal carcinoma treatment.
| Sr. No. | Drug | Nanocarrier | Cell line | Findings | Reference |
|---|---|---|---|---|---|
| 1. | Irinotecan (IRT) | Poly ethylene glyco (PEG)-conjugated hyaluronic acid nanoparticles | HT29 human colorectal carcinoma | IRT-P-HA-NPs exhibited significant suppression of tumour growth with a reduced systemic toxicity | [38] |
| 2. | Piperlongumine | Human serum albumin (HAS) nanoparticles | HCT 116 | Enhanced cytotoxicity and greater induction of apoptosis compared to free drug | [7] |
| 3. | Curcumin | Chitosan-pectinate nanoparticulate system | HT-29 | Increased uptake, anticancer activity and oral bioavailability | [39] |
| 5. | Capecitabine | Single-walled carbon nanotubes (SWCNTs) | Caco-2 | Increased intrinsic activity and non-toxic | [40] |
| 6. | Doxorubicin | Mesoporous silica nanoparticles (MSNs) | LoVo cells | Increased apoptosis and therapeutic efficacy | [41] |
| Venturini et al. [42] | |||||
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