^99mTc-RWY SPECT/CT imaging of a 52-year-old woman with clinical stage II breast cancer in the left breast and the expression level of integrin α6 in breast cancer. (a, b) Transverse, (c, d) coronal, and (e, f) sagittal plane CT and SPECT/CT. SPECT/CT images of the chest obtained 0.5 h p.i. displayed intense 99mTc-RWY accumulation in the cancer tissue in the left breast (white arrow). (g) Hematoxylin–eosin (HE) staining confirmed the presence of tumor cells in the section indicated by the white arrow. Scale bar, 100 μm. (h) Immunohistochemical staining indicated high integrin α6 expression in the area with high radioactivity accumulation. The figure and legend are modified and reproduced with permission from [56] under the terms of the Creative Commons CC BY license.