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Figure 4


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Experimental validation for compounds QP6 and QP7. Predicted binding modes of QP6 (A) and QP7 (B) in complex with CBP protein. The inhibitory curves of QP6 (C) and QP7. Half-maximum inhibitory concentration (IC50) values for QP6 (C) and QP7 (D) in AlphaScreen assay. (E) Selectivity profile of QP6 and QP7. Bromodomains’ selectivity profiles were determined by AlphaScreen.

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