Figure 4

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Image and data of polysaccharide-induced tumor calcification. a) Fluorescent detection of calcified HeLa cells by confocal laser scanning microscopy (CLSM) shows the form of calcium phosphate (CaP) after cancer cell targeting calcification (CCTC) treatment, calcium mineral was stained by Calcein (green), the cell membrane was stained by PKH26 (red), and the nucleus was stained by Hoechst33342 (blue). b) Quantitative analysis of cell viability with different treatments (**P < 0.01). c) Micro-computed tomography (micro-CT) detection of the tumors shows in vivo CCTC treatment effects on tumors. The left column shows a three-dimensional reconstruction, and the right was a typical tomography section marked on the left. d) Normalized tumor growth curves in the control, DOX, and CCTC treatment groups (volume vs. time). e) Tumor metastasis detection by in vivo imaging (mice) and ex vivo imaging (organs); organs included the heart. f) Optical observation of pulmonary metastasis (circles). g) Survival rates of the tumor mice after DOX and CCTC treatment (n = 10). **P < 0.01.
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