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Alteration of ACE2 expression in the tumor does not affect patients’ overall survival rates in patients with colorectal adenocarcinoma or gastric adenocarcinoma. The median value of ACE2 expression evaluated by IHC (3.5 for the gastric cancer cohort and 6 for the colorectal cancer cohort) was used as a cutoff value to separate patients into a low versus high expression group. Although the patients with elevated ACE2 expression in their tumors had favorable survival potential, no statistical significance was found in either cancer cohort.

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